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Ontogeny of neural mechanisms of episodic memory
Šafová, Lucie ; Nekovářová, Tereza (advisor) ; Blahna, Karel (referee)
Two brain structures in particular - the hippocampus and the prefrontal cortex (PFC) - are essential for episodic memory, the ability to recall personal experiences with details of time, place, and event. It is their developmental changes that contribute significantly to the progressive development of episodic memory. The hippocampus is a complex structure composed of several subregions that is crucial to the function of the neural basis of episodic memory. Findings show that both neuronal changes within the hippocampus and changes in its volume and the volume of hippocampal subfields influence episodic memory. As in the hippocampus, changes in the prefrontal cortex also affect episodic memory, with the PFC being among the last regions to fully mature and affecting the accuracy of recalling contextual details of episodic memories. The transfer of information between brain regions is also crucial for episodic memories, and is provided by white matter connections (fornix, cingulum, uncinate fasciculus). This thesis summarizes the knowledge about the structures and mechanisms involved in the development of episodic memory and mentions the factors that influence its development. Keywords: episodic memory, ontogeny, hippocampus, prefrontal cortex, synaptic plasticity
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Retrospective analysis focused on finding the most successful clubs in the education of young hockey talents in the 70s, 80s and 90s in the Czech Republic
RŮŽEK, Josef
The aim of this bachelor thesis was to find out the most successful clubs in development of young hockey players in seventies, eighties, and nineties in Czech Republic. In the analytical part we were interested in development of ice-hockey player and physiological conditions. We were also concerned with professional army sport. In synthetic part we mentioned all ice-hockey clubs, which played their part in developing top ice-hockey players. We also described five best ice-hockey clubs. We found out that in last 30 years there were 202 representational players, including 21 goalkeepers, 69 defenders and 112 attackers, on major tournaments. The most successful club was HC Dukla Jihlava, because of their program, which helped 54 players till they reach twenty years of age.
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Hormonal synchronization of fetal circadian clocks in suprachiasmatic nuclei
Kapsdorferová, Viktória ; Sumová, Alena (advisor) ; Sehadová, Hana (referee)
Rhythmic non-light maternal signals, such as various behavioral, neurohumoral or metabolic factors, may play a key role in synchronization of the fetal circadian clock. This diploma thesis focuses more closely on the possible role of leptin and dopamine in the hormonal synchronization of the fetal central clock resides in the suprachiasmatic nuclei of the hypothalamus. A transgenic mouse fetus, which has luciferase fused to the clock gene Period 2, was used as an experimental model. This allowed us to monitor the operation of the fetal central clock in real time by recording the bioluminescence of tissue explants. Exogenous administration of dopamine during the decline in bioluminescence at normalized circadian time 15 induces larger phase delays compared to vehicle. Leptin, on the other hand, can participate in the development of spontaneous rhythms by stabilizing the integrity of the circadian rhythm, manifested by slowing down the rhythm dampening. At the level of individual cellular oscillators, significant regional differences in amplitude and period were not observed using bioluminescence microscopy. However, a slight dispersion of cell phases was observed after administration of dopamine during decreasing bioluminescence. In the case of leptin, there was a prolongation of period of the cell...
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triggers of asexual reproduction: on the crosslink between hybridization, asexuality, polyploidy and speciation on example of Cobitidae loaches
Marta, Anatolie ; Janko, Karel (advisor) ; Arai, Katsutoshi (referee) ; Trachtulec, Zdeněk (referee)
(in English) Sexual reproduction is considered a nearly universal feature of all eukaryotic organisms and has been hypothesized to be their ancestral state. Sexual reproduction is mainly represented by meiotic division, recombination, production of haploid gametes and fertilization. Although molecular and cytological mechanisms underlying meiosis are highly conservative they may be disrupted in numerous ways leading to the emergence of so-called asexual lineages. The proximate origins of asexuality may differ for particular taxa. In vertebrates, asexuality frequently is triggered by interspecific hybridization. Nowadays "classical" theories predict that asexuals should not be able to persist on a long-term evolutionary scale. However, the hybrid lineages have to overcome short-term disadvantages, such as postzygotic barriers ranging from complete hybrid sterility to altered meiosis resulting in asexual reproduction and even ploidy elevation. Despite that hybrid sterility is one of the most common outcomes of interspecific hybridization, however various lineages found their ways to alleviate these problems and produce viable clonal gametes. The knowledge about proximate mechanisms of unreduced gamete formation in asexual lineages is very limited as many studies were restricted due to methodological...
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Consequences of perinatal insult on brain excitability in immature and adult rats
Fábera, Petr ; Mareš, Pavel (advisor) ; Pokorný, Jaroslav (referee) ; Ošlejšková, Hana (referee)
Perinatal insult may lead to a permanent impairment of brain function resulting in the development of epilepsy. Status epilepticus (SE) in immature rats leads to hippocampal hyperexcitability. The functional and morphological changes of the hippocampus are similar to those seen in human temporal lobe epilepsy. The excitability may be influenced by adenosine. Adenosine acts its anticonvulsant effect by activation of A1 receptors (A1R). The concentration of adenosine is regulated by adenosine kinase (ADK) present in two isoforms - ADK-L and -S. The main goal of the thesis is to elucidate the changes in A1R and ADK isoforms expression during intact brain development and after SE. A1R agonist 2-chloro-N6- cyclopentyladenosine (CCPA), as well as inhibition of ADK by 5-iodotubercidin (5-ITU), may bolster the anticonvulsant effect, but their action may correspond with the level of A1R and ADK. Hippocampal excitability in immature rats after LiCl-pilocarpine SE was studied by the model of hippocampal afterdischarges (ADs) and correlated with changes of A1R and ADK in the hippocampus. ADs demonstrated significantly decreased hippocampal excitability shortly after SE induction, whereas significant hyperexcitability accompanied by spontaneous seizures in older rats was shown. Increasing ADK-S expression...
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Possibilities of physiotherapy for patients with postdysplastic coxarthrosis
KRÁL, Tomáš
This bachelor thesis deals with the possibilities of influencing the health status of patient with conservatively treated posdysplastic coxarthrosis through physiotherapy, as well as maintaining patient´s highest possible quality of life. The theoretical part includes a description of the hip joint anatomy, including the description of surrounding muscles and their function, which take part in the hip kinesiology. More detailed kinesiology and biomechanics are defined in a special chapter. Another section of theoretical part deals with the topic of physiological development of the hip joint, as well as the description of the nature of dysplasia. Furthermore, this part deals with the topic of osteoarthritis, with focus on osteoarthritis of the hip joint, caused by dysplasia. This chapter is directly followed by description of physiotherapeutic solutions for this problem. As the conclusion of the theoretical part is the description of the operational solutions and their indications. The aim of the theoretical part was to summarize the information about the kinesiology of the hip joint and the possible consequences of disrupting its physiology into a comprehensive set. Furthermore, the aim was to provide the summary of information about physiotherapeutic approaches and other solutions to this problem. This can be used as a more detailed informational material for patients, or as an ancillary material for physiotherapists. The practical part was realized with the use of qualitative research, from which were the obtained data processed in the form of individual case reports, which include both inputand output- kinesiological examinations, course of those therapies and long-term and short-term therapeutic plan. Three patients diagnosed with postdysplastic coxarthrosis participated in the study. In all tested probands, there was a certain kind of influence on functional pathological changes. Post-exercise and resting pain were alleviated. The therapy also brought positive changes in hip stabilization and increased the HSSP activation. Overall, there was an improvement in soft tissue adhesion and a reduction in pain produced by tissue reflex changes. Two patients also had a slight improvement in gait stereotype and overall posture. One of the results was also the stretching and light strengthening of certain muscles and muscle groups.
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Using games and contests in English language teaching at elementary school level.
NOVOTNÝ, Kryštof
Abstract This Diploma Thesis deals with using games and competitions in teaching of English for the first level of primary schools. The aim of the thesis is to characterize the role of the game in English language teaching and its possible use in order to develop key language skills. The theoretical part deals with the psychological characteristics of the younger school age, then the theory of play and the developmental stages of children's play. In the last part of the thesis, there are described the different types of didactic games. The practical part consists of two parts. The first part presents didactic games, that are properly commented in terms of general educational and language objectives. Each of them was taught and reflected in terms of its effectiveness. The second chapter of the practical part presents the results of the research, which was conducted in the form of a guided interview with English language teachers at the elementary school, dealing with their experience in using English language lessons at primary school.
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Rhythmic function of placenta and the impact of disruption in maternal-placental-fetal axis
Světlíková, Nela ; Sumová, Alena (advisor) ; Pačesová, Dominika (referee)
In mammals, the circadian rhythms result of a complex endogenous system consisting of hierarchically organized oscillators. The system enables the synchronization of the organism's internal processes with the external environment. It consists of the main component, the central clock, located in the suprachiasmatic nuclei in the hypothalamus, and peripheral clocks in other cells, tissues and organs. The placenta is a temporary, specialized mammalian organ that is part of the mother-placenta-fetus axis and exhibits rhythmicity in its functions. The aim of this thesis is to summarize the rhythmic functions of the placenta, such as immunity, protection, and production of hormones and other mediators that play an important role in fetal development and pregnancy. In addition, the thesis also describes rhythmic changes, that occur during pregnancy in the mother-placenta-fetus axis and how these rhythms influence each other. Keywords Placenta, circadian clock, ontogenesis, fetus, maternal synchronization, hormones, enzymes, immunity
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Effect of maternal obesity on postnatal development of circadian clocks
Sejrková, Veronika ; Sumová, Alena (advisor) ; Spišská, Veronika (referee)
This thesis focuses on the synchronizing effect of obesity in mothers on ontogenesis of the circadian system in their offspring during gestation and postnatal life. Additionally, the work summarizes its impact on health of offspring in adulthood. During postnatal life, the central clock oscillator (SCN) is synchronized with external conditions through alternating period of light and darkness, but during prenatal ontogenesis of the main oscillator and peripheral oscillators, the SCN is synchronized with maternal signals, both behavioral, metabolic and hormonal. In the event of disruption of the maternal circadian and metabolic systems due to obesity, the circadian clocks of the offspring are incorrectly synchronized during gestation and breastfeeding, which may have a long-term effect on their health later during postnatal life. Maternal obesity is considered the main trigger for obesity occurring later.
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